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Big Data Analytics Can Predict Individualized Risk of Metabolic Syndrome in Patients: Study

June 27, 2014
by John DeGaspari
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Large-scale patient data analytics can help create personalized, early intervention for patients

Analysis of patient records using state-of-the-art data analytics can predict future risk of metabolic syndrome, according to research published in The American Journal of Managed Care.

More than a third of the U.S. population has metabolic syndrome, a condition that can lead to chronic heart disease, stroke and diabetes. These conditions combine to account for almost 20 percent of overall health care costs in the U.S. The study was conducted by Aetna and GNS Healthcare Inc, a provider of big data analytics products and services in health care.

“This study demonstrates how integration of multiple sources of patient data can help predict patient-specific medical problems,” said lead author Dr. Gregory Steinberg, head of clinical innovation at Aetna Innovation Labs, in a prepared statement. “We believe the personalized clinical outreach and engagement strategies, informed by data from this study, can help improve the health of people with metabolic syndrome and reduce the associated costs.”

GNS analyzed data from nearly 37,000 members of one of Aetna’s employer customers who had voluntarily participated in screening for metabolic syndrome. The data analyzed included medical claims records, demographics, pharmacy claims, lab tests and biometric screening results over a two-year period. For this study, the Aetna and GNS teams used two distinct analytical models:

  • A claims-based-only model to predict the probability of each of the five metabolic syndrome factors occurring for each study subject.
  • A second model based on both claims and biometric data to predict whether each study subject is likely to get worse, improve or stay the same for each metabolic syndrome factor.

Both analytical models predicted future risk of metabolic syndrome on both a population and an individual level. The researchers were able to develop detailed risk profiles for individual participants, enabling a deep understanding of exactly which combination of the five metabolic syndrome factors each of the study subjects exhibit and are at risk for developing. For every Aetna member whose data was used in the study, the researchers used a scale that measures the percentage risk that individuals have of exhibiting each of the five metabolic syndrome factors. For example, in an individual patient who exhibited two of the five risk factors, researchers could predict which third factor is the most likely to develop.

The analytical models also helped identify individual variable impact on risk associated with adherence to prescribed medications, as well as adherence to routine, scheduled outpatient doctor visits. A scheduled, outpatient visit with a primary care physician lowers the one-year probability of having metabolic syndrome in nearly 90 percent of individuals. In addition, the study found that improving waist circumference and blood glucose yielded the largest benefits on patients’ subsequent risk and medical costs.




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