PCORI Board Funds 14 Clinical Effectiveness Research Projects | Healthcare Informatics Magazine | Health IT | Information Technology Skip to content Skip to navigation

PCORI Board Funds 14 Clinical Effectiveness Research Projects

November 21, 2017
by David Raths
| Reprints
Total includes $32 million to fund three large-scale pragmatic clinical studies

The Patient-Centered Outcomes Research Institute (PCORI) board of governors has approved $57 million to fund 14 new comparative clinical effectiveness research (CER) studies. The funds will support studies of a range of conditions and problems that impose high burdens on patients, caregivers and the healthcare system.   

That total includes $32 million to fund three large-scale pragmatic clinical studies. Such studies represent an effort to produce results that are broadly applicable to a greater variety of patients and care situations and can be more quickly taken up in routine clinical practice than traditional clinical research results. The newly approved awards are:

• $13.6 million for a study based at UCLA that will compare whether a health-system-based strategy or a community-based strategy to support caregivers and individuals with dementia is more effective at keeping people in their homes and reducing caregiver stress and depression.

• $11.9 million for a University of Florida project comparing two forms of radiation therapy for prostate cancer — traditional X-ray therapy, called intensity-modulated radiation therapy (IMRT), and a newer treatment called proton therapy, which uses less radiation but costs more.

• $6.5 million for a study led by the UCLA Fielding School of Public Health to compare strategies for increasing the use of the human papillomavirus (HPV) vaccine among Latino populations, which have a lower rate of HPV vaccination than the general population. This project will compare three interventions: a clinic-based approach that includes training staff on discussing the vaccine with patients and their parents; a parent-based approach that involves strategies to notify and encourage parents outside the clinic, such as text reminders and letters; and a combined clinic-based and parent-based based approach.

“Like all of our pragmatic clinical studies, these new awards will help answer significant questions regarding treatment and delivery of care that are important to patients and those who care for them,” said PCORI Executive Director Joe Selby, MD, MPH. “These large studies feature the engagement of stakeholder groups on the research team and have been judged as having a high potential to change practice and improve patients’ outcomes.”

The board also approved $25 million for 11 additional studies, including:

• $4.9 million for a University of Washington project that addresses how best to deliver collaborative, patient-centered care for trauma survivors. The study will determine which of two approaches to the care of injured patients results in improving post-injury function and concerns, PTSD symptoms, and emergency department utilization. One approach uses a collaborative-care Intervention that includes frontline trauma staff and peer support, while the other involves trauma staff teamed with mental health consultation.

• $2.8 million to the Georgetown University Medical Center for a randomized controlled study of treatments for anxiety disorders to compare the effectiveness of mindfulness treatment to escitalopram, a standard medication for people with anxiety disorders. Many individuals are reluctant to take psychiatric medications.

• $2.1 million for a Fenway Community Health Center project to improve the health of sexual- and gender-minority patients by comparing patients’ outcomes and satisfaction with care before and after clinicians participate in a training program about providing culturally competent care and collecting data on sexual orientation and gender identity.

• $1.9 million for RTI International to determine whether health systems can improve rates of retention of patients in substance abuse treatment and patient outcomes by applying a systematic approach to matching patients with addiction treatment developed by the American Society of Addiction Medicine, as opposed to traditional methods. This study will compare outcomes of health systems that implement the matching approach with those that opt not to.

With these latest awards, PCORI has invested $2 billion to fund more than 400 patient-centered CER studies and other projects designed to enhance CER methods and the infrastructure necessary to conduct CER rigorously and efficiently.



Get the latest information on Health IT and attend other valuable sessions at this two-day Summit providing healthcare leaders with educational content, insightful debate and dialogue on the future of healthcare and technology.

Learn More



Advocate Aurora Health, Foxconn Plan Employee Wellness, “Smart City,” and Precision Medicine Collaboration

Wisconsin-based Advocate Aurora Health is partnering with Foxconn Health Technology Business Group, a Taiwanese company, to develop new technology-driven healthcare services and tools.

Healthcare Data Breach Costs Remain Highest at $408 Per Record

The cost of a data breach for healthcare organizations continues to rise, from $380 per record last year to $408 per record this year, as the healthcare industry also continues to incur the highest cost for data breaches compared to any other industry, according to a new study from IBM Security and the Ponemon Institute.

Morris Leaves ONC to Lead VA Office of Electronic Health Record Modernization

Genevieve Morris, who has been detailed to the U.S. Department of Veterans Affairs (VA) from her position as the principal deputy national coordinator for the Department of Health and Human Services, will move over full time to lead the newly establishment VA Office of Electronic Health Record Modernization.

Cedars-Sinai Accelerator Program Presents Fourth Class of Startups

The Cedars-Sinai Accelerator, a program that helps entrepreneurs bring their innovative technology products to market, has brought in nine more health tech startups as part of its fourth class.

DirectTrust Adds Five Board Members

DirectTrust, a nonprofit organization that support health information exchange, announced the appointment of five new executives to its board of directors.

Analysis: Many States Continue to Have Restrictive Telemedicine Policies

State Medicaid programs are evolving to accelerate the adoption of telemedicine models, this evolution is occurring more quickly in some states than others, according to a recent analysis by Manatt Health.